![Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma](https://www.mdpi.com/cancers/cancers-12-02541/article_deploy/html/images/cancers-12-02541-g001a.png)
Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma
![Knockdown of EZH2 phenocopies GSK126 mediated inhibition in melanoma.... | Download Scientific Diagram Knockdown of EZH2 phenocopies GSK126 mediated inhibition in melanoma.... | Download Scientific Diagram](https://www.researchgate.net/publication/281260437/figure/fig3/AS:632408382640130@1527789316489/Knockdown-of-EZH2-phenocopies-GSK126-mediated-inhibition-in-melanoma-EZH2-protein-was_Q640.jpg)
Knockdown of EZH2 phenocopies GSK126 mediated inhibition in melanoma.... | Download Scientific Diagram
![Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41392-022-01034-7/MediaObjects/41392_2022_1034_Fig6_HTML.png)
Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy
![The combination of metformin and GSK126 reduced cell proliferation,... | Download Scientific Diagram The combination of metformin and GSK126 reduced cell proliferation,... | Download Scientific Diagram](https://www.researchgate.net/publication/345992169/figure/fig2/AS:1073923416412160@1633054703620/The-combination-of-metformin-and-GSK126-reduced-cell-proliferation-increased-apoptosis.jpg)
The combination of metformin and GSK126 reduced cell proliferation,... | Download Scientific Diagram
Animation showing how GSK126 allows cells to produce insulin again | cell, pancreas, gene | In a world-first, JDRF-funded researchers have turned on a gene in cells from a person with #type1diabetes
![Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma](https://www.mdpi.com/cancers/cancers-12-02541/article_deploy/html/images/cancers-12-02541-g003.png)
Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma
![JDRF researchers reprogramme donor type 1 pancreas cells to produce insulin - JDRF, the type 1 diabetes charity JDRF researchers reprogramme donor type 1 pancreas cells to produce insulin - JDRF, the type 1 diabetes charity](https://jdrf.org.uk/wp-content/uploads/2022/07/Beta-cells.png)
JDRF researchers reprogramme donor type 1 pancreas cells to produce insulin - JDRF, the type 1 diabetes charity
![Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma](https://pub.mdpi-res.com/cancers/cancers-12-02541/article_deploy/html/images/cancers-12-02541-g004a.png?1602080214)
Cancers | Free Full-Text | Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in EZH2 Gain-of-Function Mutant Diffuse Large B-Cell Lymphoma
![GSK126 an inhibitor of epigenetic regulator EZH2 suppresses cardiac fibrosis by regulating the EZH2-PAX6-CXCL10 pathway GSK126 an inhibitor of epigenetic regulator EZH2 suppresses cardiac fibrosis by regulating the EZH2-PAX6-CXCL10 pathway](https://cdnsciencepub.com/cms/10.1139/bcb-2022-0224/asset/images/bcb-2022-0224_con1.jpg)
GSK126 an inhibitor of epigenetic regulator EZH2 suppresses cardiac fibrosis by regulating the EZH2-PAX6-CXCL10 pathway
![GSK126 inhibits proliferation and causes G2/M cell cycle arrest in EZH2... | Download Scientific Diagram GSK126 inhibits proliferation and causes G2/M cell cycle arrest in EZH2... | Download Scientific Diagram](https://www.researchgate.net/publication/281260437/figure/fig2/AS:632408378454023@1527789315944/GSK126-inhibits-proliferation-and-causes-G2-M-cell-cycle-arrest-in-EZH2-mutant-and-WT.png)
GSK126 inhibits proliferation and causes G2/M cell cycle arrest in EZH2... | Download Scientific Diagram
![Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41392-022-01034-7/MediaObjects/41392_2022_1034_Fig5_HTML.png)
Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy
![Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41392-022-01034-7/MediaObjects/41392_2022_1034_Fig4_HTML.png)
Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy
Animation showing how GSK126 allows cells to produce insulin again | cell, pancreas, gene | In a world-first, JDRF-funded researchers have turned on a gene in cells from a person with #type1diabetes
![GSK 126 | EZH2 HMTase inhibitor | GSK126 | CAS [1346574-57-9] | Axon 2140 | Axon Ligand™ with >98% purity available from stock from supplier Axon Medchem GSK 126 | EZH2 HMTase inhibitor | GSK126 | CAS [1346574-57-9] | Axon 2140 | Axon Ligand™ with >98% purity available from stock from supplier Axon Medchem](https://www.axonmedchem.com/media/catalog/product/cache/1/image/9df78eab33525d08d6e5fb8d27136e95/2/1/2140.gif)
GSK 126 | EZH2 HMTase inhibitor | GSK126 | CAS [1346574-57-9] | Axon 2140 | Axon Ligand™ with >98% purity available from stock from supplier Axon Medchem
![Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor | Signal Transduction and Targeted Therapy](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41392-022-01034-7/MediaObjects/41392_2022_1034_Fig1_HTML.png)